PRP is a form of regenerative medicine that uses a patient’s own blood to promote healing and can be used to treat a variety of conditions including orthopedic injuries (ie, muscle, tendon, bone, ligament, cartilage). 

Researchers of this study wanted to evaluate the addition of hyperbaric oxygen (HBOT) with PRP therapy to determine the outcome for fracture healing. This was an animal study that used a 2-week preconditioning HBOT protocol before standard PRP (HBOP). 

This 2 week HBOT protocol consisted of 10 total sessions at 3.0 ATA, administered in three, 20 minute sessions with two 5-minute air breaks (60 total minutes at pressure).

Upon blood collection, researchers noted that HBOP produced significantly higher growth factors compared to PRP alone. In addition, bone repair was accelerated and repaired both quicker and stronger.

Furthermore, they concluded “HBOP enhances the biological activity of PRP and accelerates bone healing in a …

Hyperbaric preconditioning enhances regenerative PRP therapy and accelerates bone healing