PRP is a form of regenerative medicine that uses a patient's own blood to promote healing and can be used to treat a variety of conditions including orthopedic injuries (ie, muscle, tendon, bone, ligament, cartilage). Researchers of this study wanted to evaluate the addition of hyperbaric oxygen (HBOT) with PRP therapy to determine the outcome for fracture healing. This was an animal study that used a 2-week preconditioning HBOT protocol before standard PRP (HBOP). This 2 week HBOT protocol consisted of 10 total sessions at 3.0 ATA, administered in three, 20 minute sessions with two 5-minute air breaks (60 total minutes at pressure). Upon blood collection, researchers noted that HBOP produced significantly higher growth factors compared to PRP alone. In addition, bone repair was accelerated and repaired both quicker and stronger. Furthermore, they concluded "HBOP enhances the biological activity of PRP and accelerates bone healing in a closed femur fracture model in rats. This study highlights the regenerative potential of PRP when preconditioned with hyperbaric oxygen for use in bone fracture therapy" <view study> Read Less

Research supports the hypothesis that the combined ABA and HBOT intervention may offer additional benefits over ABA therapy alone, with verbal milestone behaviors in children with autism <view study> Read Less

Rotator cuff injures (of the shoulder) can be very difficult to treat and can cause significant limitations in the range of motion for the affected shoulder, particularly in the elderly that are at higher risk to this kind of injury. For professional athletes, an injury like this can slow down their time to 'return to play' but more importantly can limit their performance  and put them at a higher risk for re-tearing the same injured area  (as the repair tissue is not as strong, or tensile, as the original tissue before). Since hyperbaric oxygen therapy (HBOT) has both  been shown to both  speed up and increase the strength (tensile) of  the healing process for these kinds of injuries, researches in this study wanted to further explore (and document) these benefits,  particularly in relation to the  tendon-bone interface healing. Even thought this study was performed on animals (Rabbit study), it was only a 5 day study at 2.0 ATA (120 minutes each session). "The results indicate that hyperbaric oxygen therapy significantly enhances vascularization at the interface between the shoulder cuff and tendon-bone, promotes collagen fiber regeneration in the tendon, improves the tensile strength of the tendon-bone complex, and does not have a significant effect on biomechanical stability." This study is consistent with all research studies showing "QUICKER and STRONGER" tissue repair from the simple addition of HBOT <view study> Read Less

Hyperbaric oxygen therapy (HBOT) provides crucial support for helping to combat accelerating aging along with chronic degenerative condition. This simple and safe procedure provides a surplus of oxygen and cellular energy to help stimulate and enhance the body's reparative and regenerative capacities. "HBOT affects physiological processes at the genetic level by altering gene expression, delaying cell senescence, and assisting in telomere length enhancement. The positive results in a variety of indications, ranging from tissue regeneration to better cognitive function, indicate that it has enormous potential in regenerative and anti-aging therapy." and  here is a quick summary of the results from HBOT:

• HBOT showed a marked improvement in cognitive functions and neuronal health which usually declines with aging
• HBOT affects the epigenetic regulation of many critical genes results in physiological consequences in the form of anti-inflammatory effect, anti-apoptotic and regenerative functions
• The extra oxygen supply is utilized in the process of healing, tissue repair, rebuilding and regeneration.
• The effect is especially beneficial for older individuals as the overall oxygen carrying capacity and regenerative capacity diminishes with age and HBOT helps to compensate for this apparent lack of oxygen in vital processes of healing and regeneration
• <view study>

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Injury to the anterior cruciate ligament (ACL) of the knee is very common, particular in professional athletes. This can be considered a major surgery where the torn ligament is replaced with a tissue graft. The purpose of this study was to investigate the impact of hyperbaric oxygen therapy (HBOT) on graft healing following ACL reconstruction. The  HBOT protocol used in this study was "2.5 ATA, 2 h daily, for 5 consecutive days, starting from the first day after surgery" This protocol showed "improved ACL graft maturation and integration, reduced tunnel widening, and enhanced the biomechanical properties of the graft." Though this was an animal study, "the results may provide important insights into the potential clinical application of HBOT as a therapeutic intervention to enhance graft healing after ACL reconstruction, paving the way for further research in this area" <view study> Read Less