A 61-year-old right-handed male stoke patient was suffering from hemiparesis and physical weakness in the right upper limb for 2 years. He then underwent a course of hyperbaric oxygen therapy (HBOT) for 60 daily sessions at 2.0 ATA. Each session was 90 minutes and included two 5-minute air breaks. Following this simple 3 month course of HBOT, both clinical and objective hand motor improvements were observed and documented though functional brain imaging scans comparing both pre and post HBOT. From the fMRI data collected, researchers of this study were able to conclude that “HBOT induces brain plasticity and functional improvement in chronic post-stroke patients” <view study> Read Less

Most people who have had a significant brain injury will require extensive rehabilitation. They may need to relearn basic skills, such as walking or talking. The goal is to improve their abilities to perform daily activities. In this case study, a 26-year-old male, suffered a severe traumatic brain injury (TBI) from a motor vehicle accident. He was discharged after 8 months and left with significant speech, ambulation, spasticity, and cognitive issues as well as the onset of post-traumatic epilepsy. The family decided to undergo hyperbaric oxygen therapy (HBOT) and the combination of Neurofeedback (NFB) with HBOT "improved plasticity and functionality in the areas of injury and the correlated symptoms including short-term memory, personality, language, and executive function, as well as significantly reducing the incidence of seizures". These results suggest that HBOT combined with NFB may be a viable option in treating severe brain injuries and should be investigated <view study> Read Less

Intermittent hyperbaric oxygen therapy is shown to help reduce the cellular and biological aging of the body and effectively help us live longer and more important, healthier. One of the effects seen during the aging process is a decline in cerebral blood flow, causing a reduction in brain oxygen levels. Cognitive and mental performance are effected, particularly in attention and information processing speed. Hyperbaric oxygen therapy can help combat the decline in cognitive function by supplying the brain with a surplus of oxygen. In addition, the intermittent application of this procedure causes changes in oxygen tensions that promote promote beneficial regulatory protein changes (from the flux in oxygen levels from high to normal). These changes include an increase in SIRT1, HIF-1A, and a reduction in CD28^null senescent T helper and cytotoxic T cells.

• SIRT1 increases mitochondrial biogenesis (energy production) and attenuates telomere length thereby contributing to increased healthy life-span and reducing aging-related diseases.
• CD28^null senescent T helper and cytotoxic T cells are aging-associated biomarkers and lower levels are associated with reduction in aging
• HIF-1A  functions as a master regulator of cellular and systemic homeostatic response to hypoxia (low oxygen) by activating transcription of many genes, including those involved in energy metabolism, angiogenesis (creation of new blood vessels and circulation) and much more

As you can see, hyperbaric oxygen therapy produces numerous benefits for helping to counteract the negative effects seen from the aging process <view study> Read Less

The most common cause of dementia in the elderly is Alzheimer's disease (AD). Hyperbaric oxygen therapy has been reported to have numerous physiological benefits for the brain, particularly for aging or degenerative brain disorders. This review article published in the journal of Alzheimer's disease (JAD) reviewed 391 full text articles between 1980-2021. The data from these studies showed both neurocognitive benefits along with positive clinical outcome for AD. These results led the authors of this review article to advocate for the use of hyperbaric oxygen therapy for AD. They also encourage future studies to be performed for protocol development, with the goal of long-term cognitive health <view study> Read Less

Hyperbaric oxygen therapy has clinically been reported to have many benefits within the body, particularly for a wide range of neurological disorders, including spinal cord injuries , brain injuries, neurodegenerative diseases (ie,Parkinson's Alzheimer's), neurodevelopment disorders (ie, Cerebral Palsy, Autism), and peripheral nerve injuries. The beneficial effects can largely be attributed to the protective anti-oxidative and anti-inflammatory effects that this procedure promotes. “The evidence presented in this review indicates the potential of HBOT in treatment and prevention of a variety of injuries to the nervous system” <view study> Read Less