Researchers reviewed 13 studies (including both animal and human research) with a total of 693 subjects to see whether hyperbaric oxygen therapy (HBOT) helps tendon and ligament injuries heal. Overall, studies found that HBOT—alone or combined with treatments like platelet-rich plasma or injections—helped tissue heal faster and stronger, showing more organized collagen (the main building block of tendons and ligaments), better repair on a microscopic level, and quicker return of function. It also appeared to lower the chance that grafts fail after ACL surgery. <view study> Read Less

Researchers reviewed 26 adults who received hyperbaric oxygen therapy (HBOT) for persistent cognitive problems from traumatic brain injuries sustained in childhood. Each person completed at least 40 sessions of 90 minutes breathing 100% oxygen at increased pressure. After treatment, participants showed significant and large improvements in global cognition, memory, executive function, attention, and processing speed, while motor skills did not improve. Benefits were seen regardless of how long ago the injury occurred (on average ~24 years) or the original injury severity, and people with mild childhood TBIs improved similarly to those with more severe injuries. Although promising, the study was retrospective, small, and lacked a control group, so the results suggest HBOT may help long-term cognitive recovery after pediatric TBI but require confirmation in larger, controlled trials <view study> Read Less

This study is particularly relevant for the elderly population, as osteoporosis is a common condition that significantly impacts their mobility and quality of life. The results suggest that hyperbaric oxygen (HBO) therapy may promote bone regeneration and improve osteogenic activity in elderly patients, especially those with normal or osteopenic bone density. If validated through further research, these findings could lead to new treatment options for preventing fractures and enhancing bone healing, thereby improving health outcomes and independence among senior citizens in today’s society. <view study> Read Less

PRP is a form of regenerative medicine that uses a patient's own blood to promote healing and can be used to treat a variety of conditions including orthopedic injuries (ie, muscle, tendon, bone, ligament, cartilage). Researchers of this study wanted to evaluate the addition of hyperbaric oxygen (HBOT) with PRP therapy to determine the outcome for fracture healing. This was an animal study that used a 2-week preconditioning HBOT protocol before standard PRP (HBOP). This 2 week HBOT protocol consisted of 10 total sessions at 3.0 ATA, administered in three, 20 minute sessions with two 5-minute air breaks (60 total minutes at pressure). Upon blood collection, researchers noted that HBOP produced significantly higher growth factors compared to PRP alone. In addition, bone repair was accelerated and repaired both quicker and stronger. Furthermore, they concluded "HBOP enhances the biological activity of PRP and accelerates bone healing in a closed femur fracture model in rats. This study highlights the regenerative potential of PRP when preconditioned with hyperbaric oxygen for use in bone fracture therapy" <view study> Read Less

Research supports the hypothesis that the combined ABA and HBOT intervention may offer additional benefits over ABA therapy alone, with verbal milestone behaviors in children with autism <view study> Read Less