Intermittent hyperbaric oxygen therapy is shown to help reduce the cellular and biological aging of the body and effectively help us live longer and more important, healthier. One of the effects seen during the aging process is a decline in cerebral blood flow, causing a reduction in brain oxygen levels. Cognitive and mental performance are effected, particularly in attention and information processing speed. Hyperbaric oxygen therapy can help combat the decline in cognitive function by supplying the brain with a surplus of oxygen. In addition, the intermittent application of this procedure causes changes in oxygen tensions that promote promote beneficial regulatory protein changes (from the flux in oxygen levels from high to normal). These changes include an increase in SIRT1, HIF-1A, and a reduction in CD28^null senescent T helper and cytotoxic T cells.

• SIRT1 increases mitochondrial biogenesis (energy production) and attenuates telomere length thereby contributing to increased healthy life-span and reducing aging-related diseases.
• CD28^null senescent T helper and cytotoxic T cells are aging-associated biomarkers and lower levels are associated with reduction in aging
• HIF-1A  functions as a master regulator of cellular and systemic homeostatic response to hypoxia (low oxygen) by activating transcription of many genes, including those involved in energy metabolism, angiogenesis (creation of new blood vessels and circulation) and much more

As you can see, hyperbaric oxygen therapy produces numerous benefits for helping to counteract the negative effects seen from the aging process <view study> Read Less

Obesity and diabetes are both prevalent and rapidly increasing in the aging population, leading to impairment in cardiac function. In this study, rats were given a chemical compound (D-Galactose) to accelerate the aging process and produce cardiac dysfunction. The rats were pre-diabetic and  were given hyperbaric oxygen therapy 60 minutes 2.0 ATA daily. With the addition of hyperbaric therapy, the rats were able to show improvements in cardiac function, along with many other benefits. Here are the authors' conclusions for this study: "Our results indicated that hyperbaric oxygen therapy (HBOT) could restore the normal cardiac function in either aging induced by D-gal rats or high-fat diet induced pre-diabetic rats. Mechanistically, HBOT effectively alleviated the cardiac dysfunction in aging pre-diabetic rats through decreased oxidative stress, inflammation, apoptosis, dysfunctional mitochondria, metabolic and autophagic impairments. Thus, HBOT could be a potential therapeutic intervention in aging pre-diabetic people with impaired cardiac function" <view study> Read Less

The most common cause of dementia in the elderly is Alzheimer's disease (AD). Hyperbaric oxygen therapy has been reported to have numerous physiological benefits for the brain, particularly for aging or degenerative brain disorders. This review article published in the journal of Alzheimer's disease (JAD) reviewed 391 full text articles between 1980-2021. The data from these studies showed both neurocognitive benefits along with positive clinical outcome for AD. These results led the authors of this review article to advocate for the use of hyperbaric oxygen therapy for AD. They also encourage future studies to be performed for protocol development, with the goal of long-term cognitive health <view study> Read Less

The combination of aging and obesity play major factors in the accelerated aging and degeneration of the brain. Commonly seen symptoms are characterized by problems with memory, language, thinking or judgment. In this study, a simple 2 week course of hyperbaric oxygen therapy was shown to be effective in restoring cognitive function. The protocol used was 2.0 ATA, 80 minutes daily, for 14 days. The researchers noted that "HBOT restored insulin sensitivity, hippocampal functions, cognition in aging and aging-obese models" in this study done on rats <view study> Read Less

Telomere length serves as a biological clock to determine our lifespan.  Every year, our telomeres (the ends of our DNA) get shorter until they finally shorten to a length that leads to our mortality. Over the past few decades, researchers and drug companies have focused (and invested substantial capital) on this  key biological determinant (telomere length) in the hopes of being able to stop and reverse the aging process. Since many age-related diseases (like cancer, cardiovascular diseases, diabetes and Alzheimer’s) are also linked to shortened telmeres, it is easy to see why so many drug and nutritional companies have been working hard on finding a cure to stop and reverse the shortening of telomeres. Hyperbaric oxygen therapy has already been demonstrated in clinical studies to help the aging population by reducing the signs of aging and age-related diseases. In 2006, a landmark study showed an 800% increase in stem cell mobilization from a course of hyperbaric oxygen therapy. This gave us a much better understanding of the physiological benefits of this procedure in relation to the aging process. Today we have even more information as a second landmark study has been published on the effects of hyperbaric  therapy in regards to telomere length. In this study, a 3 month course of hyperbaric therapy produced a profound increase in telomere length by 20% - 38%. (This is higher than any other intervention currently available). The hyperbaric protocol used to produce these benefits included 60 hyperbaric sessions (each at 90 minute sessions at 2.0 ATA  with 3 air breaks). This exciting new study will surely lead to many more telomere-based studies in the field of hyperbaric oxygen therapy and further help to advance our knowledge of this therapy.  <View Full Study in the JOURNAL OF AGING> Due to the significance of this study, it has quickly been picked up by many news associations like the following:

• <view in the Independent>
• <view in yahoo news>
• <view in the telegraph>
• <view in aljazeera>
• <view in Science alert>
• <view in Neuroscience news>

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