Human brown adipose tissue (BAT) can be activated to increase glucose uptake and energy expenditure, making it a potential target for treating obesity and metabolic disease. Brown fat produces heat to help maintain your body temperature in cold conditions and its glucose uptake is ~8-fold higher than that of skeletal muscles, on average, per gram of tissue during mild cold exposure In this animal study, a 7 day course of hyperbaric oxygen therapy was able to cause an increase glucose uptake while also inducing BAT development, leading the authors to conclude that “HBO therapy as a novel method of inducing BAT development, considering its therapeutic potential for the treatment of metabolic disorders” <view study> Read Less

This exciting new study shows that Hyperbaric Oxygen therapy (HBOT) may REVERSE dementia development by preventing the deposit of new amyloid plaques on the brain cells and even leading to the removal of existing ones! The 2 most common types of dementia are vascular dementia and Alzheimer’s disease (AD). It is now believed that hyperbaric oxygen therapy can effectively help to halt both of these devastating conditions, while also being able to help reverse the cognitive decline seen in the aging process. The production of amyloid plaques are a hallmark of AD, consisting of hard, insoluble accumulations of beta amyloid proteins that clump together between the nerve cells and block their communication. Compounding this, is a reduction in oxygen (hypoxia) and reduction in blood flow to these regions inside the brain. Since the pathophysiology includes both the build up of amyloid plaques and a reduction in cerebral blood flow (CBF), the researchers designed this study to deploy a typical course of HBOT and then observe any changes in both amyloid plaque and CBF, while also documenting any clinical improvements. They did this by presenting a 2-fold study, the first being an animal study which was then followed up with a small human study. Both showed extremely promising results and confirmed previous studies for HBOT’s potential role in treating dementia and memory loss. Initial Animal Study: Mice were exposed to 20 HBOT sessions (2.0 ATA, 60 min) causing a significant:

• Reduction in amyloid burden (by reducing the volume of pre-existing plaques and attenuating the formation of new ones).
• Improvement in vascular parameters
• Improvement in behavior and performance of cognitive-based tasks.

Human follow-up study: Six elderly patients with significant memory loss were treated with 60 HBOT sessions (2.0 ATA, 90 min) and both CBF and cognitive function were evaluated and the results were as follows:

• Cerbral Blood Flow — Following HBOT, there were significant CBF increases in several brain areas, including 8 Brodmann areas.
• Cognitive function — Cognitive assessment revealed a significant increase in the global cognitive score, where memory, attention and information processing speed domain scores showed most benefits. The improvements in these scores correlated with improved short and working memory.

This study, along with previous studies by these authors, demonstrates that hyperbaric oxygen therapy can be deployed at any stage of the dementia process, from early on with mild cognitive impairment, to advanced stages seen in Alzheimer's. disease. <view study> <view media Exclusive: Alzheimer’s could be ‘halted’ using oxygen therapy> Read Less

Pulmonary fibrosis is a chronic progressive lung disease that is becoming more prevalent and poses medical challenges due to the limited therapeutic options available. The rise in the aging process along with the rise in pulmonary complications from long COVID has led to new research studies to help identify potential treatment options. Hyperbaric oxygen therapy (HBOT) is emerging as one of them, showing good promise with clinical outcome measures. To demonstrate HBOT's influence on this disease, researchers in this study first exposed a group of rats to bleomycin (a chemotherapeutic agent that is known to cause acute pulmonary toxicity) directly into the trahea. This is to induce pulmonary fibrosis. They waited 7 days and then treated the rats with 14 days of HBOT at 2.5 ATA  for 90 minutes. The rats that were treated with this 2 week course of HBOT demonstrated a marked reduction in TGF-β, which is normally elevated and plays an active role in the development of the fibrosis.  The findings in this study support the use of HBOT as a potential "life changing" therapy for patients with pulmonary fibrosis <view study> Read Less

Intermittent hyperbaric oxygen therapy is shown to help reduce the cellular and biological aging of the body and effectively help us live longer and more important, healthier. One of the effects seen during the aging process is a decline in cerebral blood flow, causing a reduction in brain oxygen levels. Cognitive and mental performance are effected, particularly in attention and information processing speed. Hyperbaric oxygen therapy can help combat the decline in cognitive function by supplying the brain with a surplus of oxygen. In addition, the intermittent application of this procedure causes changes in oxygen tensions that promote promote beneficial regulatory protein changes (from the flux in oxygen levels from high to normal). These changes include an increase in SIRT1, HIF-1A, and a reduction in CD28^null senescent T helper and cytotoxic T cells.

• SIRT1 increases mitochondrial biogenesis (energy production) and attenuates telomere length thereby contributing to increased healthy life-span and reducing aging-related diseases.
• CD28^null senescent T helper and cytotoxic T cells are aging-associated biomarkers and lower levels are associated with reduction in aging
• HIF-1A  functions as a master regulator of cellular and systemic homeostatic response to hypoxia (low oxygen) by activating transcription of many genes, including those involved in energy metabolism, angiogenesis (creation of new blood vessels and circulation) and much more

As you can see, hyperbaric oxygen therapy produces numerous benefits for helping to counteract the negative effects seen from the aging process <view study> Read Less

Obesity and diabetes are both prevalent and rapidly increasing in the aging population, leading to impairment in cardiac function. In this study, rats were given a chemical compound (D-Galactose) to accelerate the aging process and produce cardiac dysfunction. The rats were pre-diabetic and  were given hyperbaric oxygen therapy 60 minutes 2.0 ATA daily. With the addition of hyperbaric therapy, the rats were able to show improvements in cardiac function, along with many other benefits. Here are the authors' conclusions for this study: "Our results indicated that hyperbaric oxygen therapy (HBOT) could restore the normal cardiac function in either aging induced by D-gal rats or high-fat diet induced pre-diabetic rats. Mechanistically, HBOT effectively alleviated the cardiac dysfunction in aging pre-diabetic rats through decreased oxidative stress, inflammation, apoptosis, dysfunctional mitochondria, metabolic and autophagic impairments. Thus, HBOT could be a potential therapeutic intervention in aging pre-diabetic people with impaired cardiac function" <view study> Read Less