A 14 day course of hyperbaric pretreatment for 14 days (once a day at 2.5 ATA) improved mitochondrial morphology and significantly increased the levels of ATP. This study shows a “restoration of mitochondrial function” and helping to improve cellular energy levels. <view study> Read Less

Bone loss is a common problem seen in the aging population, mainly due to disuse. This is also a seen in astronauts, patients that are on extended bed rests, and in people leading a sedentary lifestyle. Disuse-induced Bone Loss is can lead to osteoporosis and higher risks of bone fractures. When bones are more frequently subjected to mechanical loads (i.e. weight-bearing exercise), bones adapt by increasing in bone mass. The opposite occurs when the bones are not regularly exposed to mechanical loads leading to a loss of bone mass and increased risk of fracture. In this study, a 10 day course of mild hyperbaric therapy (1.3 ATA) was shown to protect and counter disuse-induced bone loss while helping to enhance new bone formation. <view study> Read Less

This study found that hyperbaric oxygen treatment has a protective effect on early cognitive function, especially memory in rats with mild cognitive impairment <view study> Read Less

A total of 53 patients (42 with Alzheimers disease and 11 mild cognitive impairment) were treated with a 20 day course of hyperbaric oxygen therapy. Each hyperbaric session consisted of 3 sequential parts; first, 20 minutes of oxygen breathing, followed by 15 minutes of breathing air, and finally 20 minutes of breathing oxygen under pressure at 1.2 ATA. Results — One course (20 sessions) of hyperbaric oxygen therapy significantly improved cognition in both Alzheimer patients and patient with Mild Cognitive impairment, with the latter having more long term benefits (> 1 month). These results are very promising for Alzheimer patients, and suggest that it is possible that multiple courses might be the solution for giving significantly longer benefits to AD patients. More research is still needed <view study> Read Less

Hypoxia, low tissue oxygen levels, “is one of the most powerful inducers of gene expression, metabolic changes, and regenerative processes, including angiogenesis and stimulation of stem cell proliferation, migration, and differentiation”. Hyperbaric oxygen therapy causes a dramatic rise in oxygen levels during the procedure followed by a quick drop back to normal levels. As the oxygen levels drop, a temporary state of hypoxia is perceived, which causes the powerful adaptive responses towards hypoxia that was noted earlier. It takes about 3 hours following hyperbaric therapy for the blood oxygen levels to normalize. This might be why twice daily sessions separated by 4 or more hours may be a better protocol for achieving optimal physiological benefits. In saying that, by controlling the variables of oxygen concentration and pressure, it may be possible to achieve better benefits by fluctuating the oxygen dose through air breaks and adjusting the pressure, respectively, during each hyperbaric session. <view study> Read Less